Adapalene

A third-generation retinoid, available without prescription, that is unusually stable and acne-focused.

strong evidenceTypically 0.1%Avoid in pregnancyIrritancy 3/5

Adapalene targets the retinoid receptors most involved in acne, which makes it more effective than retinol for breakouts and, for many people, less irritating. It is stable in light and in combination with benzoyl peroxide, which older retinoids are not. It went over-the-counter in the US in 2016 at 0.1%.

How to use it

A pea-sized amount for the whole face. Expect a purge around weeks two to six; push through it if you can.

What it helps with

Acne · 5/5Clogged pores · 5/5Blackheads · 4/5Post acne marks · 3/5Uneven texture · 3/5

Products containing it

Differin Adapalene Gel 0.1%$13.80

Related reading

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What actually works for acne

Four ingredients with real evidence, matched to the kind of breakout you have.

Routine is educational and is not medical advice. Recommendations are generated from the answers you gave and general dermatological guidance — they cannot account for your full history. For persistent or severe skin conditions, or before starting anything new during pregnancy, speak to a doctor or dermatologist.